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lim animals  (MedChemExpress)


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    MedChemExpress lim animals
    <t>Quercetin</t> inhibits the PI3K signaling pathway and affects glycolysis. A.PIK3Ca、p- PIK3Ca 、AKT1、p-AKT1, FOXO3a, p -FOXO3a, HK2, PFKL, PKM2 and LDHA expression detected by Western blot in NC, <t>LIM,</t> DMSO, Que-L, Que-M, Que-H group in 4w and 6w. Samples derived from the same experiment and that blots were processed in parallel. B–U. Bar graphs of Western blot analysis for PIK3Ca、p- PIK3Ca 、AKT1、p-AKT1, FOXO3a, p -FOXO3a, HK2, PFKL, PKM2, and LDHA in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w. (∗∗∗P < 0.001). V. PIK3Ca, AKT1, FOXO3a immunofluorescence staining in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w. W. HK2, PFKL, and LDHA immunofluorescence staining in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w.
    Lim Animals, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 167 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/lim animals/product/MedChemExpress
    Average 95 stars, based on 167 article reviews
    lim animals - by Bioz Stars, 2026-06
    95/100 stars

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    1) Product Images from "Quercetin improves retinal glycolysis to slow myopia progression through orchestrating the AKT/FOXO/HK2 axis"

    Article Title: Quercetin improves retinal glycolysis to slow myopia progression through orchestrating the AKT/FOXO/HK2 axis

    Journal: Redox Biology

    doi: 10.1016/j.redox.2026.104139

    Quercetin inhibits the PI3K signaling pathway and affects glycolysis. A.PIK3Ca、p- PIK3Ca 、AKT1、p-AKT1, FOXO3a, p -FOXO3a, HK2, PFKL, PKM2 and LDHA expression detected by Western blot in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w. Samples derived from the same experiment and that blots were processed in parallel. B–U. Bar graphs of Western blot analysis for PIK3Ca、p- PIK3Ca 、AKT1、p-AKT1, FOXO3a, p -FOXO3a, HK2, PFKL, PKM2, and LDHA in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w. (∗∗∗P < 0.001). V. PIK3Ca, AKT1, FOXO3a immunofluorescence staining in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w. W. HK2, PFKL, and LDHA immunofluorescence staining in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w.
    Figure Legend Snippet: Quercetin inhibits the PI3K signaling pathway and affects glycolysis. A.PIK3Ca、p- PIK3Ca 、AKT1、p-AKT1, FOXO3a, p -FOXO3a, HK2, PFKL, PKM2 and LDHA expression detected by Western blot in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w. Samples derived from the same experiment and that blots were processed in parallel. B–U. Bar graphs of Western blot analysis for PIK3Ca、p- PIK3Ca 、AKT1、p-AKT1, FOXO3a, p -FOXO3a, HK2, PFKL, PKM2, and LDHA in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w. (∗∗∗P < 0.001). V. PIK3Ca, AKT1, FOXO3a immunofluorescence staining in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w. W. HK2, PFKL, and LDHA immunofluorescence staining in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w.

    Techniques Used: Expressing, Western Blot, Derivative Assay, Immunofluorescence, Staining

    Effect of quercetin on retinal metabolism in myopia。 A. Mitochondrial membrane potential was detected in NC, LIM, DMSO, Que-L, Que-M, and Que-H groups at 6 weeks. B. Bar graphs of Mitochondrial membrane potential analysis in NC, LIM, DMSO, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗P < 0.05). C. ROS were detected in NC, LIM, DMSO, Que-L, Que-M, and Que-H groups at 6 weeks. D. Bar graphs of ROS analysis in NC, LIM, DMSO, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗P < 0.05). E. Bar graphs of LA analysis in NC, LIM, DMSO, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗P < 0.05). F. Mitochondrial respiratory function in the retina after 6 weeks of myopia induction. G. Bar graphs of basal mitochondrial respiration analysis in NC, LIM, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗∗P < 0.01, ∗P < 0.05). H. Bar graphs of maximal mitochondrial respiration analysis in NC, LIM, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗∗P < 0.01, ∗P < 0.05). I. Glycolytic function in the retina after 6 weeks of myopia induction. J. Bar graphs of glycolytic capacity analysis in NC, LIM, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗∗P < 0.01). K. Bar graphs of glycolytic reserve analysis in NC, LIM, Que-L, Que-M, Que-H group (∗∗P < 0.01, ∗P < 0.05). L. KEGG analysis of metabolites. M. Metabolite expression levels in NC, LIM, and quercetin intervention groups were analyzed by metabonomics. Blue line: glycolytic pathway; Green line: pentose phosphate pathway; Purple line: hexose branch.
    Figure Legend Snippet: Effect of quercetin on retinal metabolism in myopia。 A. Mitochondrial membrane potential was detected in NC, LIM, DMSO, Que-L, Que-M, and Que-H groups at 6 weeks. B. Bar graphs of Mitochondrial membrane potential analysis in NC, LIM, DMSO, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗P < 0.05). C. ROS were detected in NC, LIM, DMSO, Que-L, Que-M, and Que-H groups at 6 weeks. D. Bar graphs of ROS analysis in NC, LIM, DMSO, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗P < 0.05). E. Bar graphs of LA analysis in NC, LIM, DMSO, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗P < 0.05). F. Mitochondrial respiratory function in the retina after 6 weeks of myopia induction. G. Bar graphs of basal mitochondrial respiration analysis in NC, LIM, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗∗P < 0.01, ∗P < 0.05). H. Bar graphs of maximal mitochondrial respiration analysis in NC, LIM, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗∗P < 0.01, ∗P < 0.05). I. Glycolytic function in the retina after 6 weeks of myopia induction. J. Bar graphs of glycolytic capacity analysis in NC, LIM, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗∗P < 0.01). K. Bar graphs of glycolytic reserve analysis in NC, LIM, Que-L, Que-M, Que-H group (∗∗P < 0.01, ∗P < 0.05). L. KEGG analysis of metabolites. M. Metabolite expression levels in NC, LIM, and quercetin intervention groups were analyzed by metabonomics. Blue line: glycolytic pathway; Green line: pentose phosphate pathway; Purple line: hexose branch.

    Techniques Used: Membrane, Expressing

    Effects of quercetin on retinal neurons in myopia. A. 5-Min data of Ca2+ (pmol·cm −2 ·s −1 ) in the retina recorded by non-invasive micro-test technology after myopic induction for 6 weeks in NC, LIM, LIM + Fos, LIM + Empty, NC + Fos, NC + Empty groups. B. 5-Min data of Ca2+ (pmol·cm −2 ·s −1 ) in the retina recorded by non-invasive micro-test technology after myopic induction for 6 weeks in NC, LIM, empty, sh-Fos-1ul, sh-Fos-3ul, sh-Fos-5ul groups. C. 5-Min data of Ca2+ (pmol·cm −2 ·s −1 ) in the retina recorded by non-invasive micro-test technology after myopic induction for 6 weeks in NC, LIM, DMSO, Que-L, Que-M, Que-H groups. D. Analysis of the retinal Ca 2+ (pmol·cm −2 ·s −1 ) based on NMT for 6 weeks in NC, LIM, LIM + Fos, LIM + Empty, NC + Fos, NC + Empty groups (∗∗∗P < 0.001, ∗P < 0.05). E. Analysis of the retinal Ca 2+ (pmol·cm −2 ·s −1 ) based on NMT for 6 weeks in NC, LIM, empty, sh-Fos-1ul, sh-Fos-3ul, sh-Fos-5ul groups (∗∗∗∗P < 0.0001. ∗∗P < 0.01). F. Analysis of the retinal Ca 2+ (pmol·cm −2 ·s −1 ) based on NMT for 6 weeks in NC, LIM, DMSO, Que-L, Que-M, Que-H groups (∗∗∗∗P < 0.0001. ∗∗P < 0.01). G. The synapses of the NC, LIM, Que-H, sh-Fos-5ul, and LIM + Fos groups were detected by TEM. The red arrows indicate synapses. H. The mitochondria of the NC, LIM, Que-H, sh-Fos-5ul, and LIM + Fos groups were detected by TEM. The green arrows indicate mitochondria. I: The TEM was used to measure the synaptic lengths of the NC, LIM, Que-H, sh-Fos-5ul and LIM + Fos groups. J. The mean values of axial length in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, LIM + Fos, LIM + Empty, NC + Fos, NC + Empty groups (∗∗∗∗P < 0.0001, ∗∗∗P < 0.001). K. The mean values of axial length in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, empty, sh-Fos-1ul, sh-Fos-3ul, sh-Fos-5ul groups (∗∗∗∗P < 0.0001, ∗∗P < 0.01, ∗P < 0.05). L. The mean values of axial length in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, DMSO, Que-L, Que-M, Que-H groups (∗∗∗∗P < 0.0001, ∗∗∗P < 0.001). M. The mean values of refraction in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, LIM + Fos, LIM + Empty, NC + Fos, NC + Empty groups (∗∗∗∗P < 0.0001, ∗∗∗P < 0.001). N. The mean values of refraction in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, empty, sh-Fos-1ul, sh-Fos-3ul, sh-Fos-5ul groups (∗∗∗∗P < 0.0001, ∗P < 0.05). O. The mean values of refraction in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, DMSO, Que-L, Que-M, Que-H groups (∗∗∗∗P < 0.0001, ∗∗∗P < 0.001).
    Figure Legend Snippet: Effects of quercetin on retinal neurons in myopia. A. 5-Min data of Ca2+ (pmol·cm −2 ·s −1 ) in the retina recorded by non-invasive micro-test technology after myopic induction for 6 weeks in NC, LIM, LIM + Fos, LIM + Empty, NC + Fos, NC + Empty groups. B. 5-Min data of Ca2+ (pmol·cm −2 ·s −1 ) in the retina recorded by non-invasive micro-test technology after myopic induction for 6 weeks in NC, LIM, empty, sh-Fos-1ul, sh-Fos-3ul, sh-Fos-5ul groups. C. 5-Min data of Ca2+ (pmol·cm −2 ·s −1 ) in the retina recorded by non-invasive micro-test technology after myopic induction for 6 weeks in NC, LIM, DMSO, Que-L, Que-M, Que-H groups. D. Analysis of the retinal Ca 2+ (pmol·cm −2 ·s −1 ) based on NMT for 6 weeks in NC, LIM, LIM + Fos, LIM + Empty, NC + Fos, NC + Empty groups (∗∗∗P < 0.001, ∗P < 0.05). E. Analysis of the retinal Ca 2+ (pmol·cm −2 ·s −1 ) based on NMT for 6 weeks in NC, LIM, empty, sh-Fos-1ul, sh-Fos-3ul, sh-Fos-5ul groups (∗∗∗∗P < 0.0001. ∗∗P < 0.01). F. Analysis of the retinal Ca 2+ (pmol·cm −2 ·s −1 ) based on NMT for 6 weeks in NC, LIM, DMSO, Que-L, Que-M, Que-H groups (∗∗∗∗P < 0.0001. ∗∗P < 0.01). G. The synapses of the NC, LIM, Que-H, sh-Fos-5ul, and LIM + Fos groups were detected by TEM. The red arrows indicate synapses. H. The mitochondria of the NC, LIM, Que-H, sh-Fos-5ul, and LIM + Fos groups were detected by TEM. The green arrows indicate mitochondria. I: The TEM was used to measure the synaptic lengths of the NC, LIM, Que-H, sh-Fos-5ul and LIM + Fos groups. J. The mean values of axial length in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, LIM + Fos, LIM + Empty, NC + Fos, NC + Empty groups (∗∗∗∗P < 0.0001, ∗∗∗P < 0.001). K. The mean values of axial length in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, empty, sh-Fos-1ul, sh-Fos-3ul, sh-Fos-5ul groups (∗∗∗∗P < 0.0001, ∗∗P < 0.01, ∗P < 0.05). L. The mean values of axial length in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, DMSO, Que-L, Que-M, Que-H groups (∗∗∗∗P < 0.0001, ∗∗∗P < 0.001). M. The mean values of refraction in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, LIM + Fos, LIM + Empty, NC + Fos, NC + Empty groups (∗∗∗∗P < 0.0001, ∗∗∗P < 0.001). N. The mean values of refraction in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, empty, sh-Fos-1ul, sh-Fos-3ul, sh-Fos-5ul groups (∗∗∗∗P < 0.0001, ∗P < 0.05). O. The mean values of refraction in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, DMSO, Que-L, Que-M, Que-H groups (∗∗∗∗P < 0.0001, ∗∗∗P < 0.001).

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    lim animals  (MedChemExpress)
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    MedChemExpress lim animals
    <t>Quercetin</t> inhibits the PI3K signaling pathway and affects glycolysis. A.PIK3Ca、p- PIK3Ca 、AKT1、p-AKT1, FOXO3a, p -FOXO3a, HK2, PFKL, PKM2 and LDHA expression detected by Western blot in NC, <t>LIM,</t> DMSO, Que-L, Que-M, Que-H group in 4w and 6w. Samples derived from the same experiment and that blots were processed in parallel. B–U. Bar graphs of Western blot analysis for PIK3Ca、p- PIK3Ca 、AKT1、p-AKT1, FOXO3a, p -FOXO3a, HK2, PFKL, PKM2, and LDHA in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w. (∗∗∗P < 0.001). V. PIK3Ca, AKT1, FOXO3a immunofluorescence staining in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w. W. HK2, PFKL, and LDHA immunofluorescence staining in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w.
    Lim Animals, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/lim animals/product/MedChemExpress
    Average 95 stars, based on 1 article reviews
    lim animals - by Bioz Stars, 2026-06
    95/100 stars
    		  Buy from Supplier

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    Quercetin inhibits the PI3K signaling pathway and affects glycolysis. A.PIK3Ca、p- PIK3Ca 、AKT1、p-AKT1, FOXO3a, p -FOXO3a, HK2, PFKL, PKM2 and LDHA expression detected by Western blot in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w. Samples derived from the same experiment and that blots were processed in parallel. B–U. Bar graphs of Western blot analysis for PIK3Ca、p- PIK3Ca 、AKT1、p-AKT1, FOXO3a, p -FOXO3a, HK2, PFKL, PKM2, and LDHA in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w. (∗∗∗P < 0.001). V. PIK3Ca, AKT1, FOXO3a immunofluorescence staining in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w. W. HK2, PFKL, and LDHA immunofluorescence staining in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w.

    Journal: Redox Biology

    Article Title: Quercetin improves retinal glycolysis to slow myopia progression through orchestrating the AKT/FOXO/HK2 axis

    doi: 10.1016/j.redox.2026.104139

    Figure Lengend Snippet: Quercetin inhibits the PI3K signaling pathway and affects glycolysis. A.PIK3Ca、p- PIK3Ca 、AKT1、p-AKT1, FOXO3a, p -FOXO3a, HK2, PFKL, PKM2 and LDHA expression detected by Western blot in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w. Samples derived from the same experiment and that blots were processed in parallel. B–U. Bar graphs of Western blot analysis for PIK3Ca、p- PIK3Ca 、AKT1、p-AKT1, FOXO3a, p -FOXO3a, HK2, PFKL, PKM2, and LDHA in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w. (∗∗∗P < 0.001). V. PIK3Ca, AKT1, FOXO3a immunofluorescence staining in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w. W. HK2, PFKL, and LDHA immunofluorescence staining in NC, LIM, DMSO, Que-L, Que-M, Que-H group in 4w and 6w.

    Article Snippet: To evaluate the effect of quercetin on myopia progression, we used quercetin with a purity of ≥98.06% (HY-18085, MCE, China) to treat LIM animals.

    Techniques: Expressing, Western Blot, Derivative Assay, Immunofluorescence, Staining

    Effect of quercetin on retinal metabolism in myopia。 A. Mitochondrial membrane potential was detected in NC, LIM, DMSO, Que-L, Que-M, and Que-H groups at 6 weeks. B. Bar graphs of Mitochondrial membrane potential analysis in NC, LIM, DMSO, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗P < 0.05). C. ROS were detected in NC, LIM, DMSO, Que-L, Que-M, and Que-H groups at 6 weeks. D. Bar graphs of ROS analysis in NC, LIM, DMSO, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗P < 0.05). E. Bar graphs of LA analysis in NC, LIM, DMSO, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗P < 0.05). F. Mitochondrial respiratory function in the retina after 6 weeks of myopia induction. G. Bar graphs of basal mitochondrial respiration analysis in NC, LIM, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗∗P < 0.01, ∗P < 0.05). H. Bar graphs of maximal mitochondrial respiration analysis in NC, LIM, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗∗P < 0.01, ∗P < 0.05). I. Glycolytic function in the retina after 6 weeks of myopia induction. J. Bar graphs of glycolytic capacity analysis in NC, LIM, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗∗P < 0.01). K. Bar graphs of glycolytic reserve analysis in NC, LIM, Que-L, Que-M, Que-H group (∗∗P < 0.01, ∗P < 0.05). L. KEGG analysis of metabolites. M. Metabolite expression levels in NC, LIM, and quercetin intervention groups were analyzed by metabonomics. Blue line: glycolytic pathway; Green line: pentose phosphate pathway; Purple line: hexose branch.

    Journal: Redox Biology

    Article Title: Quercetin improves retinal glycolysis to slow myopia progression through orchestrating the AKT/FOXO/HK2 axis

    doi: 10.1016/j.redox.2026.104139

    Figure Lengend Snippet: Effect of quercetin on retinal metabolism in myopia。 A. Mitochondrial membrane potential was detected in NC, LIM, DMSO, Que-L, Que-M, and Que-H groups at 6 weeks. B. Bar graphs of Mitochondrial membrane potential analysis in NC, LIM, DMSO, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗P < 0.05). C. ROS were detected in NC, LIM, DMSO, Que-L, Que-M, and Que-H groups at 6 weeks. D. Bar graphs of ROS analysis in NC, LIM, DMSO, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗P < 0.05). E. Bar graphs of LA analysis in NC, LIM, DMSO, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗P < 0.05). F. Mitochondrial respiratory function in the retina after 6 weeks of myopia induction. G. Bar graphs of basal mitochondrial respiration analysis in NC, LIM, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗∗P < 0.01, ∗P < 0.05). H. Bar graphs of maximal mitochondrial respiration analysis in NC, LIM, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗∗P < 0.01, ∗P < 0.05). I. Glycolytic function in the retina after 6 weeks of myopia induction. J. Bar graphs of glycolytic capacity analysis in NC, LIM, Que-L, Que-M, Que-H group (∗∗∗P < 0.001, ∗∗P < 0.01). K. Bar graphs of glycolytic reserve analysis in NC, LIM, Que-L, Que-M, Que-H group (∗∗P < 0.01, ∗P < 0.05). L. KEGG analysis of metabolites. M. Metabolite expression levels in NC, LIM, and quercetin intervention groups were analyzed by metabonomics. Blue line: glycolytic pathway; Green line: pentose phosphate pathway; Purple line: hexose branch.

    Article Snippet: To evaluate the effect of quercetin on myopia progression, we used quercetin with a purity of ≥98.06% (HY-18085, MCE, China) to treat LIM animals.

    Techniques: Membrane, Expressing

    Effects of quercetin on retinal neurons in myopia. A. 5-Min data of Ca2+ (pmol·cm −2 ·s −1 ) in the retina recorded by non-invasive micro-test technology after myopic induction for 6 weeks in NC, LIM, LIM + Fos, LIM + Empty, NC + Fos, NC + Empty groups. B. 5-Min data of Ca2+ (pmol·cm −2 ·s −1 ) in the retina recorded by non-invasive micro-test technology after myopic induction for 6 weeks in NC, LIM, empty, sh-Fos-1ul, sh-Fos-3ul, sh-Fos-5ul groups. C. 5-Min data of Ca2+ (pmol·cm −2 ·s −1 ) in the retina recorded by non-invasive micro-test technology after myopic induction for 6 weeks in NC, LIM, DMSO, Que-L, Que-M, Que-H groups. D. Analysis of the retinal Ca 2+ (pmol·cm −2 ·s −1 ) based on NMT for 6 weeks in NC, LIM, LIM + Fos, LIM + Empty, NC + Fos, NC + Empty groups (∗∗∗P < 0.001, ∗P < 0.05). E. Analysis of the retinal Ca 2+ (pmol·cm −2 ·s −1 ) based on NMT for 6 weeks in NC, LIM, empty, sh-Fos-1ul, sh-Fos-3ul, sh-Fos-5ul groups (∗∗∗∗P < 0.0001. ∗∗P < 0.01). F. Analysis of the retinal Ca 2+ (pmol·cm −2 ·s −1 ) based on NMT for 6 weeks in NC, LIM, DMSO, Que-L, Que-M, Que-H groups (∗∗∗∗P < 0.0001. ∗∗P < 0.01). G. The synapses of the NC, LIM, Que-H, sh-Fos-5ul, and LIM + Fos groups were detected by TEM. The red arrows indicate synapses. H. The mitochondria of the NC, LIM, Que-H, sh-Fos-5ul, and LIM + Fos groups were detected by TEM. The green arrows indicate mitochondria. I: The TEM was used to measure the synaptic lengths of the NC, LIM, Que-H, sh-Fos-5ul and LIM + Fos groups. J. The mean values of axial length in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, LIM + Fos, LIM + Empty, NC + Fos, NC + Empty groups (∗∗∗∗P < 0.0001, ∗∗∗P < 0.001). K. The mean values of axial length in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, empty, sh-Fos-1ul, sh-Fos-3ul, sh-Fos-5ul groups (∗∗∗∗P < 0.0001, ∗∗P < 0.01, ∗P < 0.05). L. The mean values of axial length in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, DMSO, Que-L, Que-M, Que-H groups (∗∗∗∗P < 0.0001, ∗∗∗P < 0.001). M. The mean values of refraction in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, LIM + Fos, LIM + Empty, NC + Fos, NC + Empty groups (∗∗∗∗P < 0.0001, ∗∗∗P < 0.001). N. The mean values of refraction in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, empty, sh-Fos-1ul, sh-Fos-3ul, sh-Fos-5ul groups (∗∗∗∗P < 0.0001, ∗P < 0.05). O. The mean values of refraction in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, DMSO, Que-L, Que-M, Que-H groups (∗∗∗∗P < 0.0001, ∗∗∗P < 0.001).

    Journal: Redox Biology

    Article Title: Quercetin improves retinal glycolysis to slow myopia progression through orchestrating the AKT/FOXO/HK2 axis

    doi: 10.1016/j.redox.2026.104139

    Figure Lengend Snippet: Effects of quercetin on retinal neurons in myopia. A. 5-Min data of Ca2+ (pmol·cm −2 ·s −1 ) in the retina recorded by non-invasive micro-test technology after myopic induction for 6 weeks in NC, LIM, LIM + Fos, LIM + Empty, NC + Fos, NC + Empty groups. B. 5-Min data of Ca2+ (pmol·cm −2 ·s −1 ) in the retina recorded by non-invasive micro-test technology after myopic induction for 6 weeks in NC, LIM, empty, sh-Fos-1ul, sh-Fos-3ul, sh-Fos-5ul groups. C. 5-Min data of Ca2+ (pmol·cm −2 ·s −1 ) in the retina recorded by non-invasive micro-test technology after myopic induction for 6 weeks in NC, LIM, DMSO, Que-L, Que-M, Que-H groups. D. Analysis of the retinal Ca 2+ (pmol·cm −2 ·s −1 ) based on NMT for 6 weeks in NC, LIM, LIM + Fos, LIM + Empty, NC + Fos, NC + Empty groups (∗∗∗P < 0.001, ∗P < 0.05). E. Analysis of the retinal Ca 2+ (pmol·cm −2 ·s −1 ) based on NMT for 6 weeks in NC, LIM, empty, sh-Fos-1ul, sh-Fos-3ul, sh-Fos-5ul groups (∗∗∗∗P < 0.0001. ∗∗P < 0.01). F. Analysis of the retinal Ca 2+ (pmol·cm −2 ·s −1 ) based on NMT for 6 weeks in NC, LIM, DMSO, Que-L, Que-M, Que-H groups (∗∗∗∗P < 0.0001. ∗∗P < 0.01). G. The synapses of the NC, LIM, Que-H, sh-Fos-5ul, and LIM + Fos groups were detected by TEM. The red arrows indicate synapses. H. The mitochondria of the NC, LIM, Que-H, sh-Fos-5ul, and LIM + Fos groups were detected by TEM. The green arrows indicate mitochondria. I: The TEM was used to measure the synaptic lengths of the NC, LIM, Que-H, sh-Fos-5ul and LIM + Fos groups. J. The mean values of axial length in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, LIM + Fos, LIM + Empty, NC + Fos, NC + Empty groups (∗∗∗∗P < 0.0001, ∗∗∗P < 0.001). K. The mean values of axial length in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, empty, sh-Fos-1ul, sh-Fos-3ul, sh-Fos-5ul groups (∗∗∗∗P < 0.0001, ∗∗P < 0.01, ∗P < 0.05). L. The mean values of axial length in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, DMSO, Que-L, Que-M, Que-H groups (∗∗∗∗P < 0.0001, ∗∗∗P < 0.001). M. The mean values of refraction in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, LIM + Fos, LIM + Empty, NC + Fos, NC + Empty groups (∗∗∗∗P < 0.0001, ∗∗∗P < 0.001). N. The mean values of refraction in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, empty, sh-Fos-1ul, sh-Fos-3ul, sh-Fos-5ul groups (∗∗∗∗P < 0.0001, ∗P < 0.05). O. The mean values of refraction in the right eyes of the guinea pigs after myopia induction for 0, 4, and 6 weeks between the NC, LIM, DMSO, Que-L, Que-M, Que-H groups (∗∗∗∗P < 0.0001, ∗∗∗P < 0.001).

    Article Snippet: To evaluate the effect of quercetin on myopia progression, we used quercetin with a purity of ≥98.06% (HY-18085, MCE, China) to treat LIM animals.

    Techniques: